Carbapenems in patients with complicated intra-abdominal infections: indications and a choice of agent

An article presents national data on antimicrobial resistance of gram-negative aerobic bacteria causing complicated intraabdominal infections. In order to improve appropriateness of empiric antibiotic therapy, we need guidelines on the choice of antimicrobial agents taking into account patient stratification by risk factors for multidrug resistant pathogens. Results of clinical trials demonstrating efficacy of carabapenems, including doripenem, in complicated intra-abdominal infections management are described. A critical role of antibiotic quality issue in severe bacterial infections is also discussed.

Key words

Intra-abdominal infections, peritonitis, antimicrobial resistance, carbapenems, doripenem, Enterobacte ria ceae, P. aeruginosa.