The inter leukin-1&beta inhibitors for the treatment of familial Mediterranean fever and other autoinflammatory diseases: CLUSTER trial

Inherited autoinflammatory diseases are a group of familial periodic fevers that include familial Mediterranean fever, criopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency/hyperimmunoglobulin D syndrome (MKD/ HIDS), tumor necrosis factor-associated periodic syndrome (TRAPS) . Autoinflammatory syndromes are defined as conditions caused by an exaggerated innate immune system response rather than by disorder of humoral or cellular immunity. Interleukin-1b is a common mediator in these diseases. S), синдром дефицита мева-everal biologic agents, including canakinumab, inhibit effects of interleukin-1band were shown to be safe and effective in the treatment of CAPS), systemic juvenile idiopathic arthritis and adult-onset S). In the recent doubleblind, randomized, placebo controlled trial (CLUS), the efficacy and safety of canakinumab were shown in patients with colchicine-resistant familial Mediterranean fever, MKD/ HIDS), and TRAPS.

Key words

Autoinflammation, familial Mediterranean fever, mevalonate kinase deficiency/hyperimmunoglobulin D syndrome, TRAPS, interleukin-1β, canakinumab.