Differential diagnosis of primary progressive multiple sclerosis

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Primary progressive multiple sclerosis has a highly variable clinical presentation and can be difficult to diagnose. The article reviews the clinical and MRI manifestations of primary progressive multiple sclerosis and its differential diagnosis with other diseases, that is, secondary progressive multiple sclerosis, diseases associated with neuromyelitis optica, systemic connective tissue diseases, including systemic lupus erythematosus, Sjogren's syndrome and Behcet's syndrome, hereditary monogenic and mitochondrial diseases, chronic Borrelia encephalomyelitis, HIV infection and neurosyphilis.

Key words

Primary progressive multiple sclerosis, brain MRI, diagnostic criteria, neuromyelitis optica