Implementation of personalized medicine in Russia: clinical pharmacologist’s view

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Personalized medicine is a therapeutic approach involving the use of an individual's genetic and epigenetic information to tailor drug therapy or preventive care. Cytochrome P450 enzymes are essential for the metabolism of many medications and are a major source of variability in drug pharmacokinetics and response. Genetic polymorphism in these enzymes may influence a patient's response to commonly prescribed drug classes. Knowledge of the prevalence of the genetic polymorphism may improve the efficacy and safety of treatment.

Key words

Personalized medicine, CYP450, isoenzymes, genetic polymorphisms.