To evaluate the effect of antihypertensive therapy on clinical picture and left ventricular remodelling in patients with arterial hypertension (AH) and chronic heart failure with preserved ejection fraction (CHF-PEF).
Material and methods
We studied 104 patients at the age of 47-77 years (mean age 61.6±7.3 years) with AH and CHF-PEF (ejection fraction >50%), I-III functional class, before and after 12-week antihypertensive treatment.
Patients were distributed into 2 groups according to the grade of AH. Initially, symptoms and signs of CHF were more prominent in patients with a higher degree of AH. However, after treatment positive changes of symptoms and signs of CHF were similar in the two groups. Baseline diameter of left atrium and left ventricle and left ventricular myocardial mass were higher in patients with more severe AH. At 12 weeks, all parameters, except left atrium diameter, did not differ between the two groups.
The effective combination antihypertensive therapy in patients with 3 grade AH reduces clinical signs of CHF and improves myocardium parameters to the level in patients with 1st-2nd degree AH.
Chronic heart failure with preserved ejection fraction, arterial hypertension, left ventricular remodelling.