Still’sdiseaseinchildrenandadults: newinsights in the pathogenesis and current treatmen

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Current evidence suggest that Still’s disease is a continuum that includes pediatric and adult-onset forms. Clinical signs and symptoms of adult-onset Still’s disease (AOSD) are nonspecific. Therefore, diagnosis may be established only by ruling out every other possible disease. Corticosteroids and low-dose methotrexate are the mainstay of AOSD treatment. IL-1 and IL-6 inhibitors may be effective in refractory cases.

Key words

Adult-onset Still’s disease, autoinflammation, IL-1 inhibitors, tocilizumab.