Pain syndromes in neurological clinical practice: pathophysiology and principles of pharmacotherapy

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Pain is a complex multisystem reaction of organism that should be distinguished from the nociception – physiological mechanism involved in detecting tissue damage. This article reviews the recent advances in our understanding of pain sensation, including the primary analysis of nociceptive stimuli in spinal cord, ascending pathways, and the cortical role in pain. The most common pain relief medications are discussed. The emphasis is on advances and safety of non-steroidal antiinflammatory drugs, including aceclofenac.

Key words

Nociceptive pain, neuropathic pain, pain traffic, non-steroidal anti-inflammatory drugs, aceclofenac.