М.О. Labeko, Y.А. Belkova, S.N.Kozlov ">

Acellbia® as a substitution for MabThera® in the monotherapy for the CD-positive B-cell non-Hodgkin's lymphoma

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Material and methods

We searched for the prospective randomized clinical trials that evaluated the efficacy and safety of different brands of rituximab for the treatment of the Bcell non-Hodgkin's lymphoma. Cost-minimization analysis of Acellbia® and MabThera® treatment was conducted from the perspective of the Russian healthcare system.


One randomised controlled trial showed similar efficacy and safety of Acellbia® and MabThera® in the treatment for the CD-positive follicular non-Hodgkin's lymphoma. Substitution with Acellbia® for MabThera® was associated with cost-saving of RUB 34,913-46,824 for a single administration and RUB 139,654-187,294 for the course of therapy.


Substitution of MabThera® with Acellbia® in the monotherapy for the CD-positive B-cell follicular nonHodgkin's lymphoma is justified clinically and economically.

Key words

Rituximab, non-Hodgkin's lymphoma, import substitution.