Familial Mediterranean fever: current concepts, diagnosis and treatment

An article reviews the current concepts of pathophysiology, clinical manifestations, diagnosis and treatment of Familial Mediterranean fever. The authors discuss methods of activity assessment and approaches to the treatment of patients with colchicine resistant disease.

Key words

Familial Mediterranean fever, autoinflammatory diseases, irin, interleukin-1, inflammasome, S100A12, АА-amyloidosis, olhiine, anakinumab.