Short-termandlong-termsafety as a main criterium for the choice of anti-inflammatory agen

This review provides data on the safety of non-steroidal antiinflammatory drugs in patients with the diseases of the mus culoskeletal system. Particular attention is paid to the longterm side effects, such as effects on cartilage and accelerated aging of bone tissue. The mechanisms of cartilage aging, as well as the mechanisms of protective and damaging effect of drugs of this group are discussed.

Key words

NSAIDs, cartilage aging, aceclofenac, safety.