Clinical features of psoriasis, risk factors and associated comorbidity

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To study the approaches to treatment of patients with psoriasis of different severity and the impact of clinical mani-festations, associated risk factors and comorbid conditionson the course of psoriasis and to evalute the disease relatedquality of life of patients.

Material and methods

We recruited the Russian patients with psoriasis who participated in the international non-inter-ventional ATLAS study. Using questionnaires, we recordedthe duration and the severity of skin disease, treatment, intensity of signs and symptoms, comorbid conditions, parameters of the burden of disease, anxiety, depression, as well asagreement of physicians’ and patients’ opinions about clinical manifestations of psoriasis and efficacy of treatmen.


In the Russian centers, 300 patients with psoriasis have been enrolled in the study. Moderately severe and severe psoriasis was more common in patients aged 45 year sand older, frequently affected the open and sensitive areas of skin, and in 11% of cases was associated with anxiety and depression. Subjective symptoms and emotional disordershad negative impact on the quality of life of patients. Cardiovascular diseases, obesity, type 2 diabetes, as well aspsoriatic arthritis frequenty occurred in patients with psoriasis. Comorbidity should be taken into account when choosing the plan of investigation and treatment of patients.


Dermatologists should pay more attention tosubjective manifestations of psoriasis and emotional disorders that have negative impact on quality of life of patients.

Key words

Psoriasis, clinical manifestations, ithcing, comorbid conditions, treatment satisfaction.