Risk factors for development of new-onset diabetes after kidney transplantation

Aim

To analyse the prevalence and risk factors for development of new-onset diabetes after kidney transplantation (NODAT).

Material and methods

We retrospectively studied the medical records of patients who received a kidney transplant in 1989-2017. Factors associated with NODAT were studied in 50 patients with NODAT and 50 age and gender matched patients without NODAT. Insulin resistance and functional activity of beta-cells were evaluated using IR-HOMA and HOMA-β, respectively.

Results

Within more than one year after kidney trasplantaion, NODAT has developed in 201 (13%) of 1546 kidney transplant recipients. NODAT was associated with body mass index (р=0.001), waist circumference (р=0.031), functional activity of beta-cells (р=0.0001), and insulin resistance (р=0.05). Treatment with tacrolimus was more common in patients with NODAT than in patients without NODAT (66% and 46%, respectively, р=0.044).

Conclusion

At average of 1.3 years after kidney trans48 plantaion, every seventh patient develops NODAT that is associated with other components of metabolic syndrome and treatment of tacrolimus.

Key words

New-onset diabetes, kidney transplantation, insulin resistance, body mass index, metabolic syndrome, tacrolimus.