Risk factors for development of new-onset diabetes after kidney transplantationDownload in PDF
To analyse the prevalence and risk factors for development of new-onset diabetes after kidney transplantation (NODAT).
Material and methods
We retrospectively studied the medical records of patients who received a kidney transplant in 1989-2017. Factors associated with NODAT were studied in 50 patients with NODAT and 50 age and gender matched patients without NODAT. Insulin resistance and functional activity of beta-cells were evaluated using IR-HOMA and HOMA-β, respectively.
Within more than one year after kidney trasplantaion, NODAT has developed in 201 (13%) of 1546 kidney transplant recipients. NODAT was associated with body mass index (р=0.001), waist circumference (р=0.031), functional activity of beta-cells (р=0.0001), and insulin resistance (р=0.05). Treatment with tacrolimus was more common in patients with NODAT than in patients without NODAT (66% and 46%, respectively, р=0.044).
At average of 1.3 years after kidney trans48 plantaion, every seventh patient develops NODAT that is associated with other components of metabolic syndrome and treatment of tacrolimus.
New-onset diabetes, kidney transplantation, insulin resistance, body mass index, metabolic syndrome, tacrolimus.