Autoinflammation in the pathogenesis of gout and hyperuricemia

An article reviews the current concepts of pathogenesis and management of gout and hyperuricemia. Available evidence suggests that complications of hyperuricemia, including arterial hypertension and metabolic syndrome, are partly related to persisting low-grade inflammation. Treatment for gout should include medications that reduce serum uric acid level and inhibit autoinflammation. The authors report a rare case of AA-amyloidosis in patient with chronic gout.

Key words

Gout, hyperuricemia, hyperuricosuria, uric acid, inflammasome, interleukin-1, autoinflammation, canakinumab.