Basic pathophysiological and molecular mechanisms of chronic venous diseases and their pharmacological correction

Chronic venous diseases (CVD) are a group of disorders of the circulatory system, which are associated with deterioration of health-related quality of life of patients, frequent surgical interventions and significant economic costs for the health care system. Signs and symptoms of CVD limit the social and КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ И ТЕРАПИЯ, 2019, 28 (3) professional activities of patients and result in loss in working time and disability. Increased venous hydrostatic pressure and endothelial dysfunction have been established to be the leading factors in CVD pathogenesis. The progression of the disease leads to remodeling of the vessels and trophic disorders. Currently, several classes of both natural and synthetic medications are being used for treatment of CVD. They relieve signs and symptoms of CVD and may correct certain pathogenetic disorders. The drugs with proven pleotropic effects may provide additional benefits in patients with CVD.

Key words

Chronic venous diseases, endothelial dysfunction, venotonics, flavonoids, ruthosides.