Autoinflammatory diseases

Autoinflammatory diseases are a group of disorders caused by a dysregulation of the innate immune system. Unlike autoimmune diseases, they are not associated with changes in humoral or cellular immunity. The authors review the current classification, clinical manifestations and treatment of various systemic autoinflammatory diseases, including cryopirinassociated periodic syndrome, familial Mediterranean fever, HIDS, and TRAPS.

Key words

Autoinflammation, cryopirin-associated periodic syndrome, familial Mediterranean fever, HIDS, TRAPS, interleukin-1, canakinumab.