Adult-onset Still's disease: perspectives on diagnosis and treatment

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Systemic-onset juvenile idiopathic arthritis (SJIA) and adultonset Still's disease (AOSD) are systemic autoinlammatory diseases of unknown aetiology that are related to similar genetically determined disorders of innate immunity. NLRP3- inflammasome dependent mechanisms of inflammation are associated with increased production of pro-inflammatory cytokines, that is, interleukin (IL)-1 and IL-18, which induce secretion of other mediators of inflammation. The article reviews the current data on pathogenesis, clinical manifestations, laboratory biomarkers and treatment of AOSD.

Key words

Adult-onset Still’s disease, interleukin-1, interleukin-6, anakinra, canakinumab, tocilizumab, biologic agents.