The socioeconomic burden of paracetamol adverse reactions over 10 years in Russia

Sirayeva G.I.: Pavlov St-Petersburg State Medical University

Kolbin A.S.: First Pavlov State Medical University, St. Petersburg

Kalyapin A.A.: IQVIA LLC, St. Petersburg

Balykina Y.E.: St. Petersburg State University, St. Petersburg, Russia

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Summary

Aim

To evaluate the socioeconomic burden of paracetamol adverse reactions.

Material and methods

We used the national database “Pharmacovigilance” as a register of paracetamol adverse reactions and calculated direct medical costs (hospitalization, stay in intensive care unit, calling an ambulance) and direct non-medical costs (temporal disability) associated with adverse drug reactions.

Results

Depending on scenario (i.e. hospitalizaion to general department or transfer to intensive care unit), the socioeconomic burden of paracetamol adverse reactions varied from 13 to 27 mln Rubles.

Conclusion

Even under the “worst” scenario (i.e. treatment in ICU), the costs of treatment for paracetamol ADRs did not exceed the cost of the drug itself, which amounted to about 8 bln Rubles over 10 years.

Key words

Paracetamol, adverse drug reactions, pharmacovigilance, pharmacoeconomics, burden, socioeconomic burden.