The socioeconomic burden of paracetamol adverse reactions over 10 years in RussiaDownload in PDF
To evaluate the socioeconomic burden of paracetamol adverse reactions.
Material and methods
We used the national database “Pharmacovigilance” as a register of paracetamol adverse reactions and calculated direct medical costs (hospitalization, stay in intensive care unit, calling an ambulance) and direct non-medical costs (temporal disability) associated with adverse drug reactions.
Depending on scenario (i.e. hospitalizaion to general department or transfer to intensive care unit), the socioeconomic burden of paracetamol adverse reactions varied from 13 to 27 mln Rubles.
Even under the “worst” scenario (i.e. treatment in ICU), the costs of treatment for paracetamol ADRs did not exceed the cost of the drug itself, which amounted to about 8 bln Rubles over 10 years.
Paracetamol, adverse drug reactions, pharmacovigilance, pharmacoeconomics, burden, socioeconomic burden.