Tumour necrosis factor receptor-associated periodic syndrome (TRAPS)

Rameev V.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Lysenko (Kozlovskaya) L.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Salugina S.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Chebotareva N.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Bulanov N.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia

Novikov A.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Barsuk M.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University

Moiseev S.: Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia

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Summary

Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) belongs to a group of rare hereditary autoinflammatory diseases (familial periodic fevers). TRAPS is characterized by the periodic occurrence of fever, abdominal pain, maculopapular rash, arthralgia/myalgia and laboratory signs of inflammation that persisit for 5 days to 3 weeks. AAamyloidosis can complicate persisting autoinlammation in TRAPS. The authors report two cases of TRAPS and discuss its diagnosis and treatment.

Key words

Autoinflammation, TRAPS, AA-amyloidosis, interleukin-1, canakinumab