Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.
Adult-onset Still’s disease, anakinra, IL-1 receptor antagonist, pregnancy, drug desensibilisation.