Targeted treatment challenges in patients with adult-onset Still’s disease

Zavrazhnova A.: Almazov National Research Medical Center

Kuvardin E.: Almazov National Research Medical Center

Myachikova V.: Almazov National Research Medical Center

Khadgidis A.: Pediatric City Multidisciplinary Clinical Center of High Technology Medical Care

Anokhina N.: Almazov National Research Medical Center

Anriyanova M.: Almazov National Research Medical Center

Kozlova Ya.: Mechnikov North-Western State Medical University, St Petersburg, Russia

Maslyanskiy A.: Almazov National Research Medical Center

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Summary

Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.

Key words

Adult-onset Still’s disease, anakinra, IL-1 receptor antagonist, pregnancy, drug desensibilisation.